Jean C. Shih

PIBBS MENTOR

Professor

Cell & Neurobiology, Molecular Pharmacology & Toxicology
Keck School of Medicine
School of Pharmacy

Research Topics

  • Neurobiology of Emotion
  • Autism and brain developmental disorders
  • MAO as Noval target for Cancer Therapeutics
  • Gene regulation and functions
  • Drug discovery and development

Research Overview

Research objectives in Shih Lab are to understand the roles of neurotransmitters on gene expression, signal transduction behaviors and ultimately diseases. They are studying the role of serotonin and dopamine in neuronal development, regulation of transcription factors in a series of monoamine oxidase (MAO) gene knock-out mice, which are animal models for anxiety, aggression and autistic-like-behavior and aggression. Recently, they showed these gene knockout mice also slowed down the progression and metastasis of prostate and brain cancers Thus provides unique animal models to study the interaction between tumors and microenvironment. Currently, Shih Lab used these KO mice model to develop novel targets for the treatment and early diagnosis of autistic-like –behaviors, prostate and brain cancer.