Professor of Allergy and Immunology
Director of Flow Cytometry Core (MMI)
Department of Molecular Microbiology & Immunology
Keck School of Medicine
- Innate Lymphoid cells
- Autoimmune diseases
- T cells
- Dendritic cells
- Glycolipid reactive T cells
- NKT cells
- Hybrid Diversity Mouse Panel genetic approaches
Research OverviewAsthma affects 17 million individuals in the United States including 5 million children or according to US Centre for Disease Control 8.2% of the US population in 2009 and is responsible for $50 billion in medical costs. The prevalence of asthma in children has dramatically increased over the last 20 years, which will result in a heightened burden in the future. Asthma represents a profound burden on healthcare provisions estimated to be responsible for 9 million visits to healthcare providers, nearly 2 million emergency room visits and almost half a million hospitalizations. Although many aspects in the development of asthma have now been elucidated the underlying cause is still unclear. This means that current therapeutic options for treatment rely on symptom management by reducing airway inflammation. The standard clinical care for allergic asthma includes bronchodilators and immunosuppressive drugs that usually must be administered indefinitely as their effects are not long lasting, are ineffective in some patients and may actually exacerbate disease severity. Many treatment options exist to manage other allergy symptoms, but targeting the unwanted immune system in patients with asthma has the potential to result in a long lasting cure. Therefore, we believe that manipulation of immunological pathways offers a new therapeutic strategy for patients with allergic asthma and our studies have the potential to lead to novel therapies.
The objective of my laboratory is to: characterize and define acquired and innate immune responses at mucosal surfaces such as lung and gut; investigate the mechanisms underlying the regulation of those responses; explore the mechanisms by which those responses contribute to inflammatory, allergic diseases and asthma; and determine means by which those responses can be specifically manipulated.
At USC my group is pursuing several investigational routes. One seeks to identify the process by which T cells and T cell subsets modulate the pathogenesis of allergic asthma. A second track targets the role of Innate cells such as Innate Lymphoid cells and dendritic cells in the modulation of immune responses and respiratory tolerance. The Third track is characterizing the genetic basis of innate and adaptive immune responses, utilizing system genetics. The fourth group is focusing on the role of costimulatory molecules in lung inflammation. Finally, the fifth group is focusing on the role of adipose resident immune cells from murine and human samples and study their role in metabolic diseases such as type 2 diabetes.