Rick A. Friedman
Professor, Otolaryngology-Head & Neck Surgery
Keck School of Medicine
The focus of my laboratory is the identification and analysis of genes and networks contributing to complex traits involving hearing and balance in humans and mice [Presbycusis (ARHI), Meniere’s Disease (MD), and Noise-Induced Hearing Loss (NIHL)]. We identified and association between ARHI and SNP variation within the GRM7 gene. We have collected the largest sample to date of individuals with Meniere's disease and seek to identify associated genes and pathways. We are incorporating a systems-based genetic approach consisting of the integration of natural genetic variation in inbred strains and molecular phenotypes (cochlear eQTL) to study ARHI and NIHL in mice. In collaboration with A. Jake Lusis, Ph.D. we are adapting the Hybrid Mouse Diversity Panel as a resource for studying complex traits in the mouse (ARHI, NIHL, and vestibular function).