Innate Immune Signal Transduction in Herpesvirus Infection and Pathogenesis
Dr. Feng’s group investigates the roles of innate immune signaling pathways in infection and pathogenesis of human oncogenic gamma herpesvirus, Kaposi’s sarcoma-associated herpesvirus (KSHV). Recently, his group has uncovered that the MAVS-dependent innate immune pathway is exploited to promote viral lytic replication and to abrogate antiviral cytokine production. Given the inflammatory nature of KSHV-associated malignancies, Dr. Feng’s laboratory is also developing animal model(s) to interrogate key functions of innate immune signaling components in inflammation-driven oncogenesis. Currently, research in Dr. Feng’s laboratory is supported by grants from NCI, NIDCR and an ACS. Moreover, Dr. Feng is a faculty that actively participates teaching of graduate students and medical students, and supervises five postdoctoral fellows and one graduate student of his team. With extensive experience in research and teaching/mentoring trainees, Dr. Feng is highly qualified to serve as a mentor for graduate students and postdoctoral fellows.