Molecular Microbiology & Immunology, Neurology
Keck School of Medicine
The research in this laboratory has been primarily related to the pathogenesis of viral infections, especially mouse coronaviruses and pathogenesis of demyelination in a murine model. We have a strong interest in the neuroendocrine influences on the immune response, in relation to brain peptides and the production of lymphokines. Newer work has been concentrated on the molecular and genetic mechanisms of degenerative disease of the nervous system. Our most recent effort is in restoring tolerance to myelin antigens in human and mouse models. We are administering a USC T cell vaccine to multiple sclerosis patients and studying the induction of tolerance by gene therapy.