Malcolm L. Snead

Affiliated Faculty

Professor

School of Dentistry
Ostrow School of Dentistry

Research Topics

  • Developmental Biology
  • Gene Regulation/Transcription

Research Overview

RESEARCH PROJECTS ONGOING OR COMPLETED DURING THE LAST 3 YEARS

"Determination and Expression of Amelogenin Gene Products"

. Principal Investigator: Malcolm L Snead, D.D.S., Ph.D.

. Agency : National Institute of Dental and Craniofacial Research

. Type: P50 (DE06988, Years, 1-16) Period: July 30, 1985 to June 30, 2001

. The major goals of this project are to test the hypothesis that amelogenin gene regulation is dependent upon a cascade of signals provided during instructive secondary germ layer interaction serving to pattern oral epithelium to the ameloblast phenotype.



"VonEbner Gland Gene Products"

. Principal Investigator: Malcolm L. Snead, D.D.S., Ph.D.

. Agency: National Institute of Dental and Craniofacial Rsearch"

. Type: R01 (DE11834, Years, 1-4) August 1, 1997 to May 31, 2001

. The major goal of this project is to investigate the function of Von Ebner Gland's products in taste transduction.



"Cell and Genetic Approaches to Enamel Biomimetics"

. Principal Investigator: Malcolm L. Snead, D.D.S., Ph.D.

. Agency: National Institute of Dental and Ccraniofacial Research

. Type: R01 (DE 13045, Years, 1-5) August 1, 1998 to June 30, 2003

. The major goal of this project is to determine the effects of selected tooth specific proteins on mineral deposition and composition in vitro; using transgenic animals as part of a gain function test, determine the effects of excessive amounts of tuftelin and ameloblastin proteins on tooth biomineralization in vivo.



"Training in Cellular and Molecular Biology"

. Principal Investigator: Malcolm L. Snead, D.D.S., Ph.D.

. Type: T32 (DE07211, Years 1-10) September 30, 1990 to June 30, 2000

. The major goal of this project is to support dentist seeking advanced training in biomedical research appropriate to the mission of the NIDCR.