Molecular Microbiology & Immunology; Molecular Pharmacology & Toxicology
Keck School of Medicine
School of Pharmacy
Cancer Cell Biology
Cell Cycle, Growth & Proliferation,
In general terms, our research is placed in the areas of molecular cancer biology and anticancer drug development. We are pursuing cross-disciplinary approaches to understand the mechanisms that determine tumor growth and chemoresistance.
We have particular interest in intracranial tumors, which can arise from primary tumor growth inside the brain (such as glioblastoma) or from metastatic spread of other cancer types (such as breast cancer or lung cancer) into the brain. Intracranial tumors are especially hard to treat, because many therapeutic agents do not cross the blood brain barrier and therefore are unable to enter the brain. With the use of animal tumor models, we are exploring novel approaches to overcome these treatment obstacles and are developing new methods and new drugs that are more effective against tumors inside the brain.