Cell and Neurobiology
Keck School of Medicine
- Membranes & Transport
- Cardiovascular & Skeletal Muscle Diseases
- Diabetes/Metabolic Diseases
Research OverviewHypertension is the leading cause of stroke and cardiovascular diseases, affecting 30% of the adult population. High blood pressure is the number one global burden of disease risk factor (Curr Hypertens Rep (2013) 15:134–136). These statistics drive our research goals.
The McDonough lab investigates the renal mechanisms responsible for regulation of blood pressure, sodium and potassium balance, how homeostasis is disrupted in disease states and corrected therapeutically. By investigating ion transporters’ phosphorylation, abundance, subcellular distribution and activity, the lab has more recently defined how stimuli such as dietary sodium and potassium, AngII, injury, and cytokines increase renal sodium transport and how the resultant hypertension provokes intrarenal responses to decrease sodium reabsorption (via pressure natriuresis). Recently we have described the transporter profiles in females vs. males as well as the physiologic consequences that account for lower BP in females before menopause. These projects have engaged the McDonough lab with expert collaborators across the USA and around the world. Dr. McDonough is a recipient of an AHA Established Investigator Award (1984-89), the 2009 E.H. Starling Distinguished Lectureship from American Physiological Society, the 2014 Donald Seldin Lectureship from the AHA, and teaching awards. She serves on editorial boards, numerous study sections, committees for the APS, AHA and ASN. Dr McDonough enjoys teaching and mentoring medical and PhD students.