Francesca Mariani

PIBBS MENTOR

Assistant Professor of Cell and Neurobiology

Department of Cell and Neurobiology
Keck School of Medicine
Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research

Research Topics

  • Developmental Biology
  • Stem Cell Biology
  • Cell Death
  • Human & Mammalian Genetics

Research Overview

During embryogenesis the balance between cell death and proliferation must be constantly regulated in order for normal development to occur. To more fully understand the molecular control of this balance, my group focuses on how seemingly homogeneous populations of cells develop into three-dimensional tissues. The lab focuses specifically on the role of growth factors during the development and regeneration of the mammalian skeleton and brain using standard and conditional knock-out techniques. These experiments are complemented by in vitro experiments using embryonic stem cells, which can be cultured to form primitive organ-like structures. In addition, we are using functional genomics to identify new gene functions and signaling pathways.