Florence M Hofman

PIBBS MENTOR

Professor

Pathology, Neurological Surgery, Ophthalmology
Keck School of Medicine

Research Topics

  • Signal Transduction
  • Cardiovascular & Skeletal Muscle Diseases
  • Cancer Biology
  • Cellular Neurobiology

Research Overview

The current research interest in the laboratory is the functional characteristics of the vasculature present within in primary and metastatic brain tumors. We have made several novel observations regarding the structure and function of these tumor-associated brain endothelial cells derived from gliomas, using both in vitro and in vivo model systems. Our results show that tumor-associated endothelial cells are relatively resistant to apoptosis induced by a variety of chemotherapeutic agents. The mechanism(s) of this chemoresistance, and ways to sensitize these vascular cells to therapeutic agents is the focus of our studies.