Baruch Frenkel

PIBBS MENTOR

Professor

Biochemistry & Molecular Biology, Orthopedic Surgery
Keck School of Medicine
Institute for Genetic Medicine

Research Topics

  • Steroid hormones in bone biology and cancer
  • Gene Regulation/Transcription

Research Overview

We are investigating interactions between steroid hormone receptors and RUNX proteins in several contexts:
1) Role of RUNX2 in glucocorticoid-induced osteoporosis.
2) Role of RUNX2 in bone-sparing effects of estrogens, androgens and SERMs.
3) Role of RUNX2 in prostate cancer and breast cancer metastasis in general and bone metastasis in particular.
4) Role of RUNX proteins, in particular RUNX1, in breast cancer suppression.