Christina Curtis

PIBBS MENTOR

Assistant Professor

Preventive Medicine
Keck School of Medicine
USC / Norris Comprehensive Cancer Center

Research Topics

  • Bioinformatics
  • Computational Biology
  • Cancer Genomics
  • Epigenetics
  • Integrative Genomics
  • Stem Cell Biology
  • Systems Biology

Research Overview

Dr Curtis'’ laboratory couples data-driven modeling with computationally-driven experimentation to address outstanding questions in cancer biology. In particular, her research exploits high-dimensional genomic data and population genetic approaches with a view to:

•Develop techniques for the systems-level analysis of genotype-phenotype associations

•Integrate multiple data types derived from sequencing and array-based technologies (genotype, copy number, mRNA and miRNA expression, and mutational profiles) to elucidate mechanisms of tumorigenesis

Interrogate intra-tumor heterogeneity and trace stem cell lineages using single cell genomic assays

•Delineate mechanisms of cancer progression and therapeutic resistance