Alan L. Epstein

PIBBS MENTOR

Professor

Pathology
Keck School of Medicine

Research Topics

  • Cancer Treatment
  • Immunology
  • Cancer Cell Biology

Research Overview

Major Areas of Research Interest

Cell culture, heterotransplantation, cytogenetics, and biological characterization of the human malignant lymphomas and leukemias; Biochemistry and immunology of nuclear proteins; Production and clinical testing of monoclonal antibodies for the immunodiagnosis and therapy of cancer.

Research In Progress

Development of humanized TNT antibodies; generation of human antibody/fusion proteins consisting of human cytokines and chemokines for the immunotherapy of cancer; development of low toxicity human IL-2 mutant; generation of human vasopermeability antibody agent to enhance drug and antibody uptake in tumors; development of antibody/enzyme fusion proteins for ADEPT; development of TNT imaging agents for the detection of solid tumors.