Cell culture, heterotransplantation, cytogenetics, and biological characterization of the human malignant lymphomas and leukemias; Biochemistry and immunology of nuclear proteins; Production and clinical testing of monoclonal antibodies for the immunodiagnosis and therapy of cancer.
Research In Progress
Development of humanized TNT antibodies; generation of human antibody/fusion proteins consisting of human cytokines and chemokines for the immunotherapy of cancer; development of low toxicity human IL-2 mutant; generation of human vasopermeability antibody agent to enhance drug and antibody uptake in tumors; development of antibody/enzyme fusion proteins for ADEPT; development of TNT imaging agents for the detection of solid tumors.
